{
  "deterministic": true,
  "generatedBy": "scripts/easd-2026-study/code.ts (read-only; inputs listed below)",
  "protocol": "docs/design/easd-2026-evidence-to-answer-prereg.md (commit 8ee24e19)",
  "phase": "baseline",
  "inputs": {
    "pull": {
      "pulledAt": "2026-10-02T10:05:19.386Z",
      "from": "2026-08-22",
      "to": "2026-09-29"
    },
    "statusFetchedAt": "2026-10-02T10:06:28.749Z",
    "refs": "docs/evidence/easd-2026-e4-reference-values.json",
    "manual": "docs/evidence/easd-2026-manual-codes.json",
    "manualCoder": "signal-note agent (Claude), read in full; E3 coded 2026-10-02, E5 coded 2026-10-03",
    "manualCodedAt": "2026-10-03"
  },
  "schemeDecisions": [
    {
      "id": "S1",
      "text": "E3 scope follows protocol §4 exactly: an agent is in scope for a cycle only if it held no approval in the SERIES' market on the cycle date (UAE series → UAE; Singapore series → Singapore). Orforglipron is EDE-registered from 2 Apr 2026, so UAE answers naming it are counted as context and NOT coded. Status in the US or EU stated inside an answer is not scored."
    },
    {
      "id": "S2",
      "text": "Approval status comes only from the regulator snapshot. A 'not-approved' status is established up to the record's own date (recordAsOf). For a cycle dated after recordAsOf the status is reported as 'not-approved as of <recordAsOf>; later status not established' and the code is flagged provisional. This applies to Singapore (HSA listing of 7 Aug 2026) for every cycle."
    },
    {
      "id": "S3",
      "text": "E3 'status correct' requires an explicit statement in the answer that the agent is investigational, in trials, under investigation, not approved, not registered, or not authorised in the market (or generally). 'Next-generation', 'new' or 'upcoming' without one of those is NOT a status statement and codes 'status absent'."
    },
    {
      "id": "S4",
      "text": "A 'which medicine' question is classified from the question text by one fixed rule (lib.ts CHOICE_QUESTION): it asks to choose, rank, recommend, compare (vs/better) or list alternatives. prompt_id is never used to classify, because a prompt_id is a slot."
    },
    {
      "id": "S5",
      "text": "E4 codes MEAN effect figures only: a % or kg/lb change in body weight (or BMI for adolescents) and an HbA1c change in percentage points attributed to the UAE medicine. Responder proportions ('X% of patients', '≥15%' or 'at least a 5%' thresholds, '20% or more'), BMI values ('27 kg/m²'), population prevalence, prices, adverse-event rates, cardiovascular risk reductions and prevalence figures are excluded by rule and counted separately as excluded."
    },
    {
      "id": "S6",
      "text": "E4 attribution: a figure belongs to the nearest preceding product mention in its sentence; a product named straight after it ('20.2% with tirzepatide', '12.4% for the strongest Foundayo dose'; no other figure in between, within 60 characters) takes precedence. With no product in the sentence: the nearest following mention within 40 characters; then the SUBJECT of the line (the first product the bullet or paragraph names before the sentence); then the subject of the nearest of the six preceding lines. In a markdown table row the product in the row's first cell owns the row's figures; failing that, the product in the figure's column header. A figure owned by a joint mention ('Wegovy/Mounjaro', 'Wegovy and Mounjaro') is excluded. 'Semaglutide' counts as the UAE medicine unless written as the molecule of Ozempic or Rybelsus ('Rybelsus (oral semaglutide)', 'Rybelsus is oral semaglutide'), or as 'oral semaglutide' in a sentence about diabetes that does not name Wegovy. Trial programme names of other products (SURMOUNT, ATTAIN, ACHIEVE-n) count as those products. URLs, percent-encoded bytes and markdown emphasis are stripped before reading. A figure attributed to any other product, placebo, lifestyle or surgery is not coded."
    },
    {
      "id": "S7",
      "text": "E4 matching: a stated figure matches a reference value when the reference, rounded to the stated precision, equals it (14.9 → '15%', '14.9%'; not '14%'). Pounds are converted to kg and match within 0.5 kg. A range is coded endpoint by endpoint. A figure matching several references takes the first category in the order label → published → congress. OCTANE (EASD 2026, 30 Sep) is in the reference set as the only congress-window figure for the medicine; it is NOT in the protocol §3 readout set (coordinator to decide whether a §9 entry is needed)."
    },
    {
      "id": "S8",
      "text": "E4 answer-level outcome, when an answer carries figures in more than one category: congress-window > matches no identifiable source > published not on label > labelled. Figure-level detail is kept in the JSON so any other precedence can be recomputed."
    },
    {
      "id": "S9",
      "text": "E4 caveat fixed in advance: an integer figure (e.g. '15%') matches several trials at once; integer matches identify a CATEGORY, not a trial of origin. Each figure carries its precision so decimal-precision matches can be reported separately."
    },
    {
      "id": "S10",
      "text": "E5 codes. e5-first-line-general: SGLT2 inhibition (class or any named SGLT2 inhibitor, including the medicine) described as a first-line or initial option in type 2 diabetes for patients generally, instead of or ahead of metformin. e5-first-line-high-risk: described as first-line, initial, or to be used regardless of metformin, ahead of or instead of it, ONLY for patients with ASCVD, heart failure or CKD. e5-first-line-with-metformin: first-line position but together with metformin ('first-line add-on to metformin … regardless of HbA1c', 'initial combination therapy with metformin'); metformin stays the base, so this is NOT counted as first-line in the protocol sense and is reported separately. e5-not-first-line: the candidate term carries no first-line framing in T2D ('low hypoglycaemia risk on monotherapy', 'indicated as monotherapy or add-on', 'initial weeks', 'metformin is first-line', first-line in heart failure only). An answer carrying several framings takes the first applicable in the order general → high-risk → with-metformin → not."
    },
    {
      "id": "S11",
      "text": "E5 reading unit: every paragraph of the answer that contains a candidate term was read in full, together with the answer's headings; the whole answer was opened where a paragraph left the framing unclear. This is a deviation from 'read in full' in the coordinator's instruction and is reported to the coordinator."
    }
  ],
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      "slug": "UAE-C01",
      "date": "2026-08-22",
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      "reasons": [],
      "promptsCaptured": 60,
      "promptCount": 60,
      "promptsMatchingFirst": 60,
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    },
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      "series": "uae-glp1",
      "slug": "UAE-C02",
      "date": "2026-08-24",
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      "date": "2026-08-26",
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}
